Cryonics in expanded dentistry and oral medicine embraces various uses of Cytotherapeutic care. Oral Cryotherapy exists in different forms. (1) Cryosurgical ablation (purposeful tissue obliteration); (2) Non-ablative cooling, mainly (take out word to) as prophylaxis of mucositis from chemotherapy; (3) Vital Pulp-testing (add in -) by pain induction for rapid vitality-pulp-testing. This review assembles clinical indications, the simple biophysics of procuring “cold-freezing-on-demand,” indicates peri-operative care, describes some ubiquitous devices and cryogens, the results of cryotherapy, lays-out pragmatic advantages/limitations and disadvantages, and stresses diagnostic safeguards for pre-malignant lesions.